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Journal Publications

2024

01

Delivery of external proteins into the cytoplasm using protein capsules modified with IgG on the surface, created from the amphiphilic two helix-bundle protein OLE-ZIP

Kousuke Takahashi, Taiki Nishiyama, Naoki Umezawa, Yasumichi Inoue, Isamu Akiba, Takehisa Dewa, Atsushi Ikeda, Toshihisa Mizuno
Chem. Commun., 2024, 60, 968.

名市大 梅澤先生・井上先生，北九大 秋葉先生，名工大 出羽先生・水野先生との共同研究の成果です。

02

Water Solubilization and Guest Molecule-Induced Fluorescence Changes of Porous Host Molecules via Complexing with Polysaccharide or Polypeptide

Sota Umezane, Toshikazu Ono, Riku Kawasaki, Atsushi Ikeda
Chem. Asian J., 2024, 19, e202301015.

九大 小野先生との共同研究の成果です。

03

Insights into mechanistic interpretation of crystalline-state reddish phosphorescence of non-planar π-conjugated organoboron compounds

Yohei Adachi, Maho Kurihara, Kohei Yamada, Fuka Arai, Yuto Hattori, Keita Yamana, Riku Kawasaki, Joji Ohshita
Chem. Sci., 2024, 15, 8127.

有機元素材料化学研究室 安達先生・大下先生との共同研究の成果です。

04

Photoacoustic Imaging Using Polysaccharide–Porphyrin Complexes by Photoirradiation at Long Wavelengths

Seiya Fujita, Riku Omokawa, Keita Yamana, Riku Kawasaki, Risako Miura, Teruyuki Kondo, Atsushi Ikeda
Chem. Asian J., 2024, Accepted Articles, e202400571.

京大 三浦先生・近藤先生との共同研究の成果です。

05

Boron agent delivery platforms based on natural products for boron neutron capture therapy

Riku Kawasaki, Yamato Miura, Nanami Kono, Seiya Fujita, Keita Yamana, Atsushi Ikeda
ChemMedChem, 2024, Accepted Articles, e202400323.

総説です。

06

Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy

Riku Kawasaki, Ayano Oshige, Nanami Kono, Keita Yamana, Hidetoshi Hirano, Yamato Miura, Ryuji Yorioka, Kaori Bando, Anri Tabata, Naoki Yasukawa, Masahiro Sadakane, Yu Sanada, Minoru Suzuki, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Dilimulati Yimiti, Shigeru Miyaki, Nobuo Adachi, Ryosuke Mizuta, Yoshihiro Sasaki, Kazunari Akiyoshi, Yoshihide Hattori, Mitsunori Kirihata, Takeshi Nagasaki, Atsushi Ikeda
ACS Appl. Mater. Interfaces, 2024, in press.

環境触媒化学研究室 定金先生，医系科学研究科 味八木先生・安達先生，京大 真田先生・鈴木先生・高田先生・櫻井先生・田中先生・佐々木先生・秋吉先生，阪公大 服部先生・切畑先生・長崎先生との共同研究の成果です。

07

Extracellular vesicles containing fullerene derivatives prepared by an exchanging reaction for photodynamic therapy

Riku Kawasaki, Nanami Kono, Ayano Oshige, Kotaro Nishimura, Keita Yamana, Dilimulati Yimiti, Shigeru Miyaki, Nobuo Adachi, Naoki Takabayashi, Takeshi Nagasaki, Atsushi Ikeda  
J. Mater. Chem. B,  2024, in press.

医系科学研究科 味八木先生・安達先生，阪公大 長崎先生との共同研究の成果です。

08

Photodynamic therapy using hybrid nanoparticles comprising of upconversion nanoparticles and chlorin e6-bearing pullulan

Riku Kawasaki, Takuro Eto, Nanami Kono, Reo Ohdake, Keita Yamana, Hidetoshi Hirano, Shogo Kawamura, Naoki Tarutani, Kiyofumi Katagiri, Atsushi Ikeda  
Biomater. Sci., 2024, Advance Article.

無機・ハイブリッド材料化学研究室 樽谷先生・片桐先生との共同研究の成果です。

2023

01

Fluorescence Sensor Using Porous Host Molecules Deposited on Filter Paper with Vapochromic and Mechanochromic Properties (Cover Picture!!)

Sota Umezane, Satoshi Fukutomi, Toshikazu Ono, Yoshio Hisaeda, Tomoki Nishimura, Riku Kawasaki, Atsushi Ikeda
New J. Chem., 2023, 47, 4166.

九大 小野先生・久枝先生，信州大 西村先生との共同研究の成果です。

02

Aqueous Solutions with Information on Solids: Room-Temperature Phosphorescence of Polysaccharide-Benzophenone Complexes

Masafumi Okuno, Keita Yamana, Riku Kawasaki, Yuto Konishi, Toshikazu Ono, Tsutomu Ishi-I, Atsushi Ikeda
RSC Adv., 2023, 13, 3528.

九大 小野先生，久留米高専 石井先生との共同研究の成果です。

03

Development of water-soluble phenazine-2,3-diol-based photosensitizers for singlet oxygen generation

Kazunori Yagi, Kazuki Ohira, Keita Yamana, Keiichi Imato, Riku Kawasaki, Atsushi Ikeda, Yousuke Ooyama
Org. Biomol. Chem., 2023, 21, 5194.

機能性色素化学研究室 今任先生・大山先生との共同研究の成果です。

04

Improvement in photodynamic activity by a porphyrin-fullerene composite system in lipid membranes

Kotaro Nishimura, Keita Yamana, Riku Kawasaki, Atsushi Ikeda
Org. Biomol. Chem., 2023, 21, 4810.

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05

HER-2-targeted boron neutron capture therapy using an antibody-conjugated boron nitride nanotube/β-1,3-glucan complex (Cover Picture!!)

Keita Yamana, Riku Kawasaki, Kousuke Kondo, Hidetoshi Hirano, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Hideki Azuma, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Tomoki Kodama, Seiji Kawamoto, Takeshi Nagasaki, Atsushi Ikeda  
Nanoscale Adv., 2023, 5, 3857.

京大 真田先生・高田先生・櫻井先生・田中先生・鈴木先生，阪公大 東先生・長崎先生，生物工学プログラム 河本先生との共同研究の成果です。

06

Drug-Loaded Biocompatible Chitosan Polymeric Films with Both Stretchability and Controlled Release for Drug Delivery

Ji Ha Lee, Tomoyuki Tachibana, Hijiri Wadamori, Keita Yamana, Riku Kawasaki, Shogo Kawamura, Hinata Isozaki, Mina Sakuragi, Isamu Akiba, Akihiro Yabuki
ACS Omega, 2023, 8, 1282.

崇城大 櫻木先生，北九州市立大 秋葉先生，化学工学プログラム Lee先生・矢吹先生との共同研究の成果です。

07

Fluorescence Turn-on of Tetraphenylethylene Derivative by Transfer from Cyclodextrin to Liposome, HeLa cells and E. coli.

Kosuke Masuda, Riku Omokawa, Riku Kawasaki, Yuta Mise, Yousuke Ooyama, Shogo Harada, Wataru Shinoda, Atsushi Ikeda
Chem. Eur. J., 2023, 29, e202203071.

岡大 篠田先生，機能性色素化学研究室 大山先生との共同研究の成果です。

08

Oncogenic RAS Networks Suppression: Reversibly Ionic Oligonucleotide-Based Nanoparticles Caged microRNA-143 Inhibit KRAS-Mutated Colon Cancer Growth in Tumor-Bearing Mice

Noriko Miyamoto, Riku Kawasaki, Mina Sakuragi, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Isamu Akiba, Yukio Kitade
Adv. Ther., 2023, 6, 2200265.

崇城大 櫻木先生，北九大 秋葉先生，愛工大 宮本先生・北出先生との共同研究の成果です。

10

Development of a Water-Dispersible Supramolecular Complex of Polyphenol with Polypeptides for Attenuation of the Allergic Response Using a Mechanochemical Strategy

Riku Kawasaki, Shogo Kawamura, Tomoki Kodama, Keita Yamana, Akira Maeda, Dilimulati Yimiti, Shigeru Miyaki, Shodai Hino, Naoki Ozawa, Tomoki Nishimura, Seiji Kawamoto, Atsushi Ikeda
Macromol. Biosci., 2023, 23, 2200462.

生物工学プログラム 河本先生，医学プログラム 味八木先生，産総研 日野博士，信州大 西村先生との共同研究の成果です。

11

Carborane Bearing Pullulan Nanogel-Boron Oxide Nanoparticle Hybrid for Boron Neutron Capture Therapy

Riku Kawasaki, Hidetoshi Hirano, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Yu Sanada, Kaori Bando, Anri Tabata, Kouhei Yoshikawa, Hideki Azuma, Takushi Takata, Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Naoki Tarutani, Kiyofumi Katagiri, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, Takeshi Nagasaki, Atsushi Ikeda
Nanomed. Nanotechnol. Biol. Med., 2023, 49, 102659.

京大 秋吉先生・佐々木先生・澤田先生・真田先生・高田先生・田中先生・櫻井先生・鈴木先生，阪公大 東先生・長崎先生，無機・ハイブリッド材料化学研究室 樽谷先生・片桐先生との共同研究の成果です。

12

Controlled Release of Drug-Encapsulated Protein Films with Various Sodium Dodecyl Sulfate Concentrations

Ji Ha Lee, Hiroya Tsubota, Tomoyuki Tachibana, Nanami Kono, Shogo Kawamura, Keita Yamana, Riku Kawasaki, Akihiro Yabuki
Chem. Sci., 2024, Advance Article.

化学工学プログラム Lee先生・矢吹先生との共同研究の成果です。

13

Phospholipid-Coated Boronic Oxide Nanoparticles as a Boron Agent for Boron Neutron Capture Therapy

Riku Kawasaki, Hidetoshi Hirano, Keita Yamana, Ayano Oshige, Kotaro Nishimura, Nanami Kono, Yu Sanada, Kaori Bando, Anri Tabata, Naoki Yasukawa, Hideki Azuma, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Minoru Suzuki, Naoki Tarutani, Kiyofumi Katagiri, Takeshi Nagasaki, Atsushi Ikeda
ChemBioChem, 2023, 24, e202300186.

京大 真田先生・高田先生・田中先生・櫻井先生・鈴木先生，阪公大 東先生・長崎先生，無機・ハイブリッド材料化学研究室 樽谷先生・片桐先生との共同研究の成果です。

14

Selective Photodynamic Activity of Tetrakis(4-Aminophenyl)Porphyrins with and without Acetyl Protecting Groups on Cancer and Normal Cells

Masafumi Okuno, Keita Yamana, Shogo Kawamura, Kotaro Nishimura, Shodai Hino, Riku Kawasaki, Atsushi Ikeda
Chem. Eur. J., 2023, 29, e202301385.

産総研 日野博士，信州大 西村先生との共同研究の成果です。

15

“On–off” Switching of Functional Guest Molecules via Exchange of Natural Product Solubilizing Agents

Riku Kawasaki, Atsushi Ikeda
ChemBioChem, 2023, 24, e202300455.

総説です。

16

HER-2-Targeted Boron Neutron Capture Therapy with Carborane-integrated Immunoliposomes Prepared via an Exchanging Reaction

Riku Kawasaki, Ayano Oshige, Keita Yamana, Hidetoshi Hirano, Kotaro Nishimura, Yamato Miura, Ryuji Yorioka, Yu Sanada, Kaori Bando, Anri Tabata, Kazuma Yasuhara, Yusuke Miyazaki, Wataru Shinoda, Tomoki Nishimura, Hideki Azuma, Takushi Takata, Yoshinori Sakurai, Hiroki Tanaka, Minoru Suzuki, Takeshi Nagasaki, Atsushi Ikeda
Chem. Eur. J., 2023, 29, e202302486.

奈良先端大 安原先生，岡大 宮﨑先生・篠田先生，信州大 西村先生，京大 真田先生・高田先生・櫻井先生・田中先生・鈴木先生，阪公大 東先生・長崎先生との共同研究の成果です。

2022

01

Water Solubilization of Paclitaxel Using Polypeptides for Cancer Therapy

Riku Kawasaki, Shogo Kawamura, Shodai Hino, Keita Yamana, and Atsushi Ikeda
Mater. Adv., 2022, 3, 467.

産総研 日野博士との共同研究の成果です。

02

Theranostic Agent Combining Fullerene Nanocrystals and Gold Nanoparticles for Photoacoustic Imaging and Photothermal Therapy

Riku Kawasaki, Kosuke Kondo, Risako Miura, Keita Yamana, Hinata Isozaki, Risako Shimada, Shogo Kawamura, Hidetoshi Hirano, Tomoki Nishimura, Naoki Tarutani, Kiyofumi Katagiri, Alexandra Stubelius, Shin-ichi Sawada, Yoshihiro Sasaki, Kazunari Akiyoshi, and Atsushi Ikeda
Int. J. Mol. Sci., 2022, 23, 4686.

京大 秋吉先生・佐々木先生・澤田先生・三浦先生，信州大 西村先生，応用化学プログラム 片桐先生・樽谷先生，Chalmers Univ. Technol., Stubelius 先生との共同研究の成果です。

03

Cyclodextrin-Induced Release of Drug-Entrapping Liposomes Associated with the Solation of Liposome Gels

Hiromu Yamada, Keita Yamana, Riku Kawasaki, Kazuma Yasuhara, and Atsushi Ikeda
RSC Adv., 2022, 12, 22202.

奈良先端大 安原先生との共同研究の成果です。

04

Formulation of Water-Dispersible Hydrophobic Compound Nanocomplexes with Polypeptides via Supramolecular Approach Using a High-Speed Vibration Milling Technique

Shogo Kawamura, Riku Kawasaki, Shodai Hino, Keita Yamana, Masafumi Okuno, Takuro Eto, and Atsushi Ikeda
RSC Adv., 2022, 12, 32012.

産総研 日野博士との共同研究の成果です。

05

Improvement of Photodynamic Activity by a Stable System Consisting of a C60 Derivative and Photo-antenna in Liposome (Cover Picture!!)

Risako Shimada, Shodai Hino Keita Yamana, Riku Kawasaki, Toshifumi Konishi, and Atsushi Ikeda
ACS Med. Chem. Lett., 2022, 13, 641.

産総研 日野博士との共同研究の成果です。

06

活性酸素種分解性ポリペプチドによるオルガネラ選択的バイオ医薬品デリバリー

山名啓太・河﨑陸
月刊アグリバイオ 2022年度8月号，66.

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07

Effect of meso Positioned Substituents on the Stability and Photodynamic Activity of Lipid-Membrane-Incorporated Porphyrin Derivatives

Kotaro Nishimura, Risako Shimada, Keita Yamana, Riku Kawasaki, Toshimi Nakaya, Atsushi Ikeda
ChemMedChem, 2022, 17, e202200070.

デジタルものづくり教育研究センター 中谷先生との共同研究の成果です。

08

Aqueous Solutions of a Porous Host-Poly-L-lysine Complex with Information on Solids as Different Fluorescence by Guests

Katsuya Takahashi, Sota Umezane, Toshikazu Ono, Satoshi Fukutomi, Megumi Ihara, Yoshio Hisaeda, Riku Kawasaki, and Atsushi Ikeda
Chem. Asian J., 2022, 17, e202200879.

九大 小野先生・久枝先生との共同研究の成果です。

2021

01

Fullerene-porphyrin hybrid nanoparticles that generate activated oxygen by photoirradiation

Kouta Sugikawa, Kosuke Masuda, Kentaro Kozawa, Riku Kawasaki, and Atsushi Ikeda
RSC Adv., 2021, 11​, 1564. 

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02

Photodynamic Therapy Using Self-Assembled Nanogels Comprising Chlorin e6 Bearing Pullulan (Cover Picture!!)

Riku Kawasaki, Reo Ohdake, Keita Yamana, Takuro Eto, Kouta Sugikawa,  and Atsushi Ikeda
J. Mater. Chem. ​B, 2021, 9​, 6357.

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03

Photo-triggered cargo release from liposome chlorin e6-bearing pullulan hybrid nanoparticles via membrane permeabilization

Riku Kawasaki, Reo Ohdake, Takuro Eto, Keita Yamana, Toshimi Nakaya, Takenori Ishida, Akio Kuroda, and Atsushi Ikeda
RSC Adv., 2021, 11, 36564.

生物工学プログラム 黒田先生・石田先生，デジタルモノづくりセンター 中谷先生との共同研究の成果です。 

04

Construction of protein-loadable protein cages using the hybrid proteins of the olefin hydrophobic domain and hydrophilic dimeric coiled-coil

Taiki Nishiyama, Kento Sugiura, Kouta Sugikawa, Atsushi Ikeda, and Toshihisa Mizuno
Colloid Int. Sci. Commun., 2021, 40, 100352.

​名工大 水野先生との共同研究の成果です。

06

Mechanism toward Turn-On of Polysaccharide-Porphyrin Complexes for Fluorescence Probes and Photosensitizes in Photodynamic Therapy in Living Cells (Cover Picture!!)

Shodai Hino, Rikushi Funada, Kouta Sugikawa, Riku Kawasaki, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, and Atsushi Ikeda
ChemMedChem, 2021, 16​, 793.

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07

Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy

Keita Yamana, Riku Kawasaki, Yu Sanada, Anri Tabata, Kaori Bando, Kouhei Yoshikawa, Hideki Azuma, Yoshinori Sakurai, Shin-ichiro Masunaga, Minoru Suzuki, Kouta Sugikawa, Takeshi Nagasaki, and Atushi Ikeda
Biochem. Biophys. Res. Commun., 2021, 559, 210.

大阪市立大 長崎先生・東先生，京大 増永先生・鈴木先生・櫻井先生との共同研究の成果です。

08

Preparation of aqueous solution with information on solids (ASIS) of a mechanochromic luminescent tetraphenylethylene detivatives by complexation with polysaccharides

Ji Ha Lee, Tomoyuki Tachibana, Keita Yamana, Riku Kawasaki, and Akihiro Yabuki
ACS Appl. Polym. Mater., 2021, 3, 3708.

信州大 西村先生，デジタルモノづくりセンター 中谷先生との共同研究の成果です。

09

Simple Formation of Cancer Drug-Containing Self-Assembled Hydrogels with Temperature and pH-Responsive Release (Cover Picture!!)

Ji Ha Lee, Tomoyuki Tachibana, Keita Yamana, Riku Kawasaki, and Akihiro Yabuki
Langmuir, 2021, 37​, 11269.

化学工学プログラム Lee先生・矢吹先生との共同研究の成果です。

2020

01

Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in β-(1,3-1,6)-D-Glucan with On-Off Switch (Cover Picture!!)

Shodai Hino, Shuhei Satake, Hideyuki Shinmori, Shigeki Kawabata, Kazuya Koumoto, Toshio Suzuki, Takeshi Nagasaki, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda
Chem. Asian J., 2020, 15​, 365. 

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02

Improved water solubility and photodynamic activity of hydroxy-modified porphyrins by complexation with cyclodextrin

Takehiro Yumoto, Shuhei Satake, Shodai Hino, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda
Org. Biomol. Chem., 2020, 18​, 6702.

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03

Bacterial elimination via the photodynamic activity of a fullerene/light-harvesting antenna molecule assembled system integrated into liposome membranes

Riku Kawasaki, Daiki Antoku, Reo Ohdake, Kouta Sugikawa, Atsushi Ikeda
Nanoscale Adv., 2020, 2, 4395.

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04

Solubilization of Tetrahydroxyphenylchlorin in Water and Improved Photodynamic Activity after Complexation with Cyclic Oligo- and Polysaccharides

Keita Yamana, Riku Kawasaki, Kouta Sugikawa, Atsushi Ikeda
ACS Appl. Bio. Mater., 2020, 3, 3217.

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05

Aggregation-Induced Emission and Retention of Crystal Chiral Information of Tetraphenylethylene Incorporated by Polysaccharides in Water

Shodai Hino, Kouta Sugikawa, Riku Kawasaki, Hisakage Funabashi, Akio Kuroda, Atsushi Ikeda
ChemPhotoChem, 2020, 4, 577.

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06

Hydrogen Sulfide-Responsive Self-Assembled Nanogel

Peng-Hao Hsu, Riku Kawasaki, Keita Yamana, Hinata Isozaki, Shogo Kawamura, Atsushi Ikeda, Adah Almutairi
ACS Appl. Polym. Mater., 2020, 2​, 3756.

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08

Water Solubilization of Phthalocyanine Derivatives via Interactions of Long Alkyl Chains and Cyclodextrins: Potential Complexes for Photodynamic Therapy

Yuya Goto, Shodai Hino, Kouta Sugikawa, Riku Kawasaki, Atsushi Ikeda
Asian J. Org. Chem., 2020, 9, 1589.

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